ER Stress Mediates TiAl6V4 Particle-Induced Peri-Implant Osteolysis by Promoting RANKL Expression in Fibroblasts

@inproceedings{Wang2015ERSM,
  title={ER Stress Mediates TiAl6V4 Particle-Induced Peri-Implant Osteolysis by Promoting RANKL Expression in Fibroblasts},
  author={Zhenheng Wang and Naicheng Liu and Tongguo Shi and Gang Zhou and Zhenzhen Wang and Jingjing Gan and Ting Qing Guo and Hongbo Qian and Nirong Bao and Jianning Zhao and Dominique Heymann},
  booktitle={PloS one},
  year={2015}
}
Wear particle-induced osteolysis is a major cause of aseptic loosening, which is one of the most common reasons for total hip arthroplasty (THA) failure. Previous studies have shown that the synovial fibroblasts present in the periprosthetic membrane are important targets of wear debris during osteolysis. However, the interaction mechanisms between the wear debris and fibroblasts remain largely unknown. In the present study, we investigated the effect of ER (endoplasmic reticulum) stress… CONTINUE READING
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