ER Re-expression and Re-sensitization to Endocrine Therapies in ER-negative Breast Cancers

@article{Brinkman2009ERRA,
  title={ER Re-expression and Re-sensitization to Endocrine Therapies in ER-negative Breast Cancers},
  author={Joeli A. Brinkman and Dorraya El-Ashry},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2009},
  volume={14},
  pages={67-78}
}
Breast cancer is the leading cause of cancer amongst women in the westernized world. The presence or absence of ERα in breast cancers is an important prognostic indicator. About 30–40% of breast cancers lack detectable ERα protein. ERα− breast cancers are resistant to endocrine therapies and have a worse prognosis than ERα+ breast cancers. Since expression of ERα is necessary for response to endocrine therapies, investigational studies are ongoing in order to understand the generation of the ER… CONTINUE READING
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