ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP).

@article{Kuang2005ERCD,
  title={ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP).},
  author={Ersheng 7 Kuang and Qingwen Wan and Xiaojuan Li and Hua Xu and Qingzhen Liu and Yipeng Qi},
  journal={Journal of cellular physiology},
  year={2005},
  volume={204 2},
  pages={549-59}
}
Perturbance of endoplasmic reticulum (ER) function, either by the mutant proteins not folding correctly, or by an excessive accumulation of proteins in the organelle, will lead to the unfolded protein response (UPR) or ER overload response (EOR). The signal-transducing pathways for UPR have been identified, whereas the pathway for EOR remains to be elucidated. Our previous study demonstrated that the overexpression of reticulon 3 (RTN3, also named HAP, homologue of ASY protein) caused apoptosis… CONTINUE READING
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