ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

@inproceedings{Stoica2014ERmitochondriaAA,
  title={ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated
TDP-43},
  author={Radu Stoica and Kurt J De Vos and S{\'e}bastien Paillusson and Sarah Luisa M{\"u}ller and Rosa M. Sancho and Kin Lau and Gema Vizcay-Barrena and Wen-lang Lin and Ya-fei Xu and Jada Lewis and Dennis W. Dickson and Leonard Petrucelli and Jacqueline C Mitchell and Christopher E. Shaw and Christopher J Miller},
  booktitle={Nature communications},
  year={2014}
}
Mitochondria and the endoplasmic reticulum (ER) form tight structural associations and these facilitate a number of cellular functions. However, the mechanisms by which regions of the ER become tethered to mitochondria are not properly known. Understanding these mechanisms is not just important for comprehending fundamental physiological processes but also for understanding pathogenic processes in some disease states. In particular, disruption to ER-mitochondria associations is linked to some… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 82 CITATIONS, ESTIMATED 67% COVERAGE

123 Citations

0204020152016201720182019
Citations per Year
Semantic Scholar estimates that this publication has 123 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

alpha-Synuclein is localized to mitochondriaassociated ER membranes

  • C Guardia-Laguarta
  • J. Neurosci
  • 2014

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer’s disease and related models

  • L Hedskog
  • Proc. Natl Acad. Sci. USA 110,
  • 2013

Similar Papers

Loading similar papers…