ERβ Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus

@article{Webb2003ERBN,
  title={ERβ Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus},
  author={Paul D. Webb and Cathleen D. Valentine and Phuong Th{\^e} Nguy{\^e}n and Richard H. Price and Adhirai Marimuthu and Brian L West and J. D. Baxter and Peter J. Kushner},
  journal={Nuclear Receptor},
  year={2003},
  volume={1},
  pages={4 - 4}
}
Nuclear receptors (NRs) usually bind the corepressors N-CoR and SMRT in the absence of ligand or in the presence of antagonists. Agonist binding leads to corepressor release and recruitment of coactivators. Here, we report that estrogen receptor beta (ERbeta) binds N-CoR and SMRT in the presence of agonists, but not antagonists, in vitro and in vivo. This ligand preference differs from that of ERalpha interactions with corepressors, which are inhibited by estradiol, and resembles that of ERbeta… CONTINUE READING
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