ERβ: recent understanding of estrogen signaling

@article{Sugiyama2010ERRU,
  title={ER$\beta$: recent understanding of estrogen signaling},
  author={Nobuhiro Sugiyama and Rodrigo P. A. Barros and Margaret Warner and Jan-{\AA}ke Gustafsson},
  journal={Trends in Endocrinology \& Metabolism},
  year={2010},
  volume={21},
  pages={545-552}
}
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TLDR
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Rapid estrogen receptor-mediated mechanisms determine the sexually dimorphic sensitivity of ventricular myocytes to 17β-estradiol and the environmental endocrine disruptor bisphenol A.
TLDR
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References

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Estrogen Receptor-β: Recent Lessons from in Vivo Studies
TLDR
A clear role for ERβ has been established in the ovary, cardiovascular system, and brain as well as in several animal models of inflammation including arthritis, endometriosis, inflammatory bowel disease, and sepsis.
Molecular cloning and characterization of human estrogen receptor βcx: A potential inhibitor of estrogen action in human
TLDR
This study indicates that ERbetacx potentially inhibits ERalpha-mediated estrogen action and that alternative splicing of the C-terminal region and its inhibitory properties are characteristic of several members of nuclear receptor isoforms.
The Dual, Opposing Roles of Estrogen in the Prostate
TLDR
It is established that estrogens have the capacity to exert both beneficial and adverse effects in the prostate via ER‐β and ER‐α, respectively, and the selective targeting of estrogen action may form the basis of new therapies for prostate disease.
Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues
TLDR
In the uterus, mammary gland and immune system, ERα promotes proliferation whereas ERβ has pro‐apoptotic and pro‐differentiating functions, so the challenge of the future will be to develop specific agonists, which can selectively activate/inactivate either ERα or ERβ.
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
TLDR
Increase in 27HC levels in mice by diet-induced hypercholesterolemia, pharmacologic administration or genetic manipulation decreased estrogen-dependent expression of vascular nitric oxide synthase and repressed carotid artery reendothelialization, indicating that 27HC functions as an endogenous selective estrogen receptor modulator (SERM).
Immunolocalization of estrogen receptor β in the mouse brain: Comparison with estrogen receptor α
TLDR
The development of an ERβ-selective antibody that cross-reacts with mouse, rat, and human ERβ protein and its use to determine the distribution of ERβ in the murine brain is reported.
Regulation and expression of human CYP7B1 in prostate: Overexpression of CYP7B1 during progression of prostatic adenocarcinoma
TLDR
It is hypothesized that CYP7B1 expression is increased in prostate tumors and that promoter methylation contributes to the regulation of CYP5α‐androstane‐3β,17β‐diol (3βAdiol) in human prostate tissue.
Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain.
TLDR
The presence and functionality of an ERalpha variant in ERalpha/betaKO brain are demonstrated and the residual binding and regulation of PR in ER alpha/ betaKO brain can be accounted for by the variant.
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