ERβ: recent understanding of estrogen signaling

  title={ER$\beta$: recent understanding of estrogen signaling},
  author={Nobuhiro Sugiyama and Rodrigo P. A. Barros and Margaret Warner and Jan-{\AA}ke Gustafsson},
  journal={Trends in Endocrinology \& Metabolism},

Estrogen receptor coregulators in brain meet the specificity of estrogen action: a possible roadmap for therapeutics

Tissue and receptor specificity of coregulators and their motifs might be useful in designing peptide specific agonist and/or antagonist which can regulate specific estrogen action and be used in therapeutics.

A new insight into estrogen signaling: Yin-Yang perspective.

The Yin-Yang theory of Traditional Chinese Medicine is integrated with modern scientific findings on estrogen signaling to offer a better understanding of the complex interactions between ERα and ERβ.

Expanding the structural footprint of xenoestrogens

Many synthetic chemicals with structural similarity to estradiol bind to the estrogen receptor and disrupt the normal estrogen physiology in humans and other vertebrates. Most of these xenoestrogens

Involvement of estrogen receptors in prostatic diseases

  • H. KawashimaT. Nakatani
  • Biology, Chemistry
    International journal of urology : official journal of the Japanese Urological Association
  • 2012
Estrogen receptor-mediated signaling in the prostate is essential together with the androgen receptor‐mediated pathway, providing a new therapeutic target for prostatic diseases.

The promiscuous estrogen receptor: Evolution of physiological estrogens and response to phytochemicals and endocrine disruptors

  • M. BakerR. Lathe
  • Biology
    The Journal of Steroid Biochemistry and Molecular Biology
  • 2018
Structural diversity in the A ring of physiological estrogens can explain the response of the ER to synthetic chemicals, which disrupt estrogen physiology in vertebrates, and the estrogenic activity of a variety of plant-derived chemicals such as genistein, coumestrol, and resveratrol.

Liganded and unliganded activation of estrogen receptor and hormone replacement therapies.

  • A. Maggi
  • Biology
    Biochimica et biophysica acta
  • 2011



Estrogen Receptor-β: Recent Lessons from in Vivo Studies

A clear role for ERβ has been established in the ovary, cardiovascular system, and brain as well as in several animal models of inflammation including arthritis, endometriosis, inflammatory bowel disease, and sepsis.

Molecular cloning and characterization of human estrogen receptor βcx: A potential inhibitor of estrogen action in human

This study indicates that ERbetacx potentially inhibits ERalpha-mediated estrogen action and that alternative splicing of the C-terminal region and its inhibitory properties are characteristic of several members of nuclear receptor isoforms.

The Dual, Opposing Roles of Estrogen in the Prostate

It is established that estrogens have the capacity to exert both beneficial and adverse effects in the prostate via ER‐β and ER‐α, respectively, and the selective targeting of estrogen action may form the basis of new therapies for prostate disease.

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Increase in 27HC levels in mice by diet-induced hypercholesterolemia, pharmacologic administration or genetic manipulation decreased estrogen-dependent expression of vascular nitric oxide synthase and repressed carotid artery reendothelialization, indicating that 27HC functions as an endogenous selective estrogen receptor modulator (SERM).

ERβ-Selective Estrogen Receptor Modulators Produce Antianxiety Behavior when Administered Systemically to Ovariectomized Rats

Together, these data suggest that actions at ERβ may underlie some of E2's antianxiety effects.

A role for estrogen receptor β in the regulation of growth of the ventral prostate

Findings suggest that ligands specific for ERβ may be useful in the prevention and/or clinical management of prostatic hyperplasia and neoplasia.

Immunolocalization of estrogen receptor β in the mouse brain: Comparison with estrogen receptor α

The development of an ERβ-selective antibody that cross-reacts with mouse, rat, and human ERβ protein and its use to determine the distribution of ERβ in the murine brain is reported.