ERβ: recent understanding of estrogen signaling

  title={ER$\beta$: recent understanding of estrogen signaling},
  author={Nobuhiro Sugiyama and Rodrigo P. A. Barros and Margaret Warner and Jan-{\AA}ke Gustafsson},
  journal={Trends in Endocrinology \& Metabolism},
A new insight into estrogen signaling: Yin-Yang perspective.
The Yin-Yang theory of Traditional Chinese Medicine is integrated with modern scientific findings on estrogen signaling to offer a better understanding of the complex interactions between ERα and ERβ.
The promiscuous estrogen receptor: Evolution of physiological estrogens and response to phytochemicals and endocrine disruptors
  • M. BakerR. Lathe
  • Biology
    The Journal of Steroid Biochemistry and Molecular Biology
  • 2018
Structural diversity in the A ring of physiological estrogens can explain the response of the ER to synthetic chemicals, which disrupt estrogen physiology in vertebrates, and the estrogenic activity of a variety of plant-derived chemicals such as genistein, coumestrol, and resveratrol.
Liganded and unliganded activation of estrogen receptor and hormone replacement therapies.
  • A. Maggi
  • Biology
    Biochimica et biophysica acta
  • 2011
Sex differences in the serum level of endogenous ligands for estrogen receptor β in the elderly population
Animal studies suggest that estrogen receptor β (ERβ)-agonists, but not ERα-agonists, are antidepressants. Several endogenous ligands for ERβ have been proposed, including 5α-androstane-3β, 17β-diol
Reporter zebrafish: endocrine disruption meets estrogen signaling.
In this issue of Endocrinology, Gorelick and Halpern (1) describe the generation and initial characterization of a genetically engineered zebrafish (Danio rerio) reporter model that monitors
The functions of estrogen receptor beta in the female brain: A systematic review.
Estrogenic environmental chemicals and drugs: Mechanisms for effects on the developing male urogenital system
Rapid estrogen receptor-mediated mechanisms determine the sexually dimorphic sensitivity of ventricular myocytes to 17β-estradiol and the environmental endocrine disruptor bisphenol A.
The sex-specific sensitivity of myocytes to estrogens and the rapid arrhythmogenic effects of BPA and estradiol in the female heart are regulated by the balance between ERα and ERβ signaling.


Estrogen Receptor-β: Recent Lessons from in Vivo Studies
A clear role for ERβ has been established in the ovary, cardiovascular system, and brain as well as in several animal models of inflammation including arthritis, endometriosis, inflammatory bowel disease, and sepsis.
Molecular cloning and characterization of human estrogen receptor βcx: A potential inhibitor of estrogen action in human
This study indicates that ERbetacx potentially inhibits ERalpha-mediated estrogen action and that alternative splicing of the C-terminal region and its inhibitory properties are characteristic of several members of nuclear receptor isoforms.
The Dual, Opposing Roles of Estrogen in the Prostate
It is established that estrogens have the capacity to exert both beneficial and adverse effects in the prostate via ER‐β and ER‐α, respectively, and the selective targeting of estrogen action may form the basis of new therapies for prostate disease.
Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues
In the uterus, mammary gland and immune system, ERα promotes proliferation whereas ERβ has pro‐apoptotic and pro‐differentiating functions, so the challenge of the future will be to develop specific agonists, which can selectively activate/inactivate either ERα or ERβ.
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
Increase in 27HC levels in mice by diet-induced hypercholesterolemia, pharmacologic administration or genetic manipulation decreased estrogen-dependent expression of vascular nitric oxide synthase and repressed carotid artery reendothelialization, indicating that 27HC functions as an endogenous selective estrogen receptor modulator (SERM).
Immunolocalization of estrogen receptor β in the mouse brain: Comparison with estrogen receptor α
The development of an ERβ-selective antibody that cross-reacts with mouse, rat, and human ERβ protein and its use to determine the distribution of ERβ in the murine brain is reported.
Regulation and expression of human CYP7B1 in prostate: Overexpression of CYP7B1 during progression of prostatic adenocarcinoma
It is hypothesized that CYP7B1 expression is increased in prostate tumors and that promoter methylation contributes to the regulation of CYP5α‐androstane‐3β,17β‐diol (3βAdiol) in human prostate tissue.
Estrogen-binding sites and their functional capacity in estrogen receptor double knockout mouse brain.
The presence and functionality of an ERalpha variant in ERalpha/betaKO brain are demonstrated and the residual binding and regulation of PR in ER alpha/ betaKO brain can be accounted for by the variant.