EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides.

@article{Goetz2014EPSAAN,
  title={EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides.},
  author={Gilles H Goetz and Laurence Philippe and Michael J. Shapiro},
  journal={ACS medicinal chemistry letters},
  year={2014},
  volume={5 10},
  pages={1167-72}
}
Most peptides are generally insufficiently permeable to be used as oral drugs. Designing peptides with improved permeability without reliable permeability monitoring is a challenge. We have developed a supercritical fluid chromatography technique for peptides, termed EPSA, which is shown here to enable improved permeability design. Through assessing the exposed polarity of a peptide, this technique can be used as a permeability surrogate.