EPO gene expression induces the proliferation, migration and invasion of bladder cancer cells through the p21WAF1‑mediated ERK1/2/NF-κB/MMP-9 pathway.

@article{Park2014EPOGE,
title={EPO gene expression induces the proliferation, migration and invasion of bladder cancer cells through the p21WAF1‑mediated ERK1/2/NF-$\kappa$B/MMP-9 pathway.},
author={Sung Lyea Park and Se Yeon Won and Jun-Hui Song and Wun-Jae Kim and S. Moon},
journal={Oncology reports},
year={2014},
volume={32 5},
pages={
2207-14
}
}
Erythropoietin (EPO) is a cytokine that modulates the production of red blood cells. Previous studies have contradicted the assumed role of EPO in tumor cell proliferation. In the present study, we investigated the effect of EPO in the proliferation, migration and invasion that is involved in the signaling pathways and cell-cycle regulation of bladder cancer 5637 cells. The results showed that an overexpression of the EPO gene has a potent stimulatory effect on DNA synthesis, migration and… Expand
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