EPIDURAL MORPHINE IN TREATMENT OF PAIN

@article{Behar1979EPIDURALMI,
  title={EPIDURAL MORPHINE IN TREATMENT OF PAIN},
  author={M. Behar and David Olshwang and Florella Magora and J. T. Davidson},
  journal={The Lancet},
  year={1979},
  volume={313},
  pages={527-529}
}
Epidural injections of a 2 mg morphine were given to 10 patients with severe acute or chronic pain. All cases had considerable amelioration of pain, which commenced within 2-3 min, reached a peak in 10-15 min, and was effective for 6-24 h. It is suggested that the morphine reached the subarachnoid space and produced its effect by direct action on the specific opiate receptors in the substantia gelatinosa of the posterior-horn cells of the spinal cord. 
Intermittent epidural morphine instillation for control of postoperative pain.
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The first instance of paraplegia in association with epidural morphine anesthesia has been reported, and significant side effects are uncommon, but pronounced respiratory depression can occur late and careful observation is necessary. Expand
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Epidural injections of morphine (2·5 or 4 mg) were given to 25 patients in labour and it is felt that this technique merits further investigation in view of its potential advantages over more traditional methods of pain relief in labour. Expand
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Assessment of pain using a visual analogue scoring system revealed no appreciable relief of pain 30 min after morphine injection, in contrast to the reported efficacy of epidural morphine 2 mg in the treatment of severe pain other than labour. Expand
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This clinical application of morphine is based on the works of Snyder, Yaksh and Rudy, which demonstrated specific opiate receptors that are distributed in the posterior horns of the spinal cord to use epidural morphine injections for postoperative pain relief. Expand
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Epidural injections of 5 mg nicomorphine in 20 ml 5% glucose were given to 10 gynaecological patients to provide intra‐operative and post‐operative analgesia to suggest that opiates produce these effects by a direct action on the endorphin “pain” modulatory system of human beings at spinal level. Expand
Epidural opioids in the management of acute surgical pain
  • A. Wolf
  • Medicine
  • Journal of psychopharmacology
  • 1991
TLDR
Epidural analgesia has now been used in obstetric practice for more than 40 years, but only in the last decade has it become an established technique for post-operative analgesia, reflecting the growing consumer demand for improved pain control after surgery. Expand
Experiences with epidular morphine in obstetrics
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Morphine (2–6 mg) injected into the epidural space was ineffective in relieving the pain of labour in eight patients and a relatively high incident of postoperative vomiting was noted among the patients who received morphine. Expand
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