EPIDEMIOLOGIC ASPECTS OF EPSTEIN‐BARR VIRUS (EBV)‐ASSOCIATED DISEASES *

@article{Henle1980EPIDEMIOLOGICAO,
  title={EPIDEMIOLOGIC ASPECTS OF EPSTEIN‐BARR VIRUS (EBV)‐ASSOCIATED DISEASES *},
  author={Werner Henle and Gertrude Henle},
  journal={Annals of the New York Academy of Sciences},
  year={1980},
  volume={354}
}
  • W. Henle, G. Henle
  • Published 1 November 1980
  • Medicine
  • Annals of the New York Academy of Sciences
It seems difficult for some students of infectious diseases to visualize how the Epstein-Barr virus (EBV) could be the cause of three quite disparate diseases; one benign, infectious mononucleosis ( IM) , and two malignant, Burkitt’s lymphoma (BL) and nasopharyngeal carcinoma (NPC). Because the first disease is largely limited to Western countries, the second most common on the African continent, and the third especially frequent in Southeast Asia, it has been suggested that different strains… Expand
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References

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Epstein‐barr virus‐specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma
TLDR
It appears that the elevated IgA levels in NPC might be due to EBV‐specific antibodies, which are similar to those obtained with sera from patients with other carcinomas or from healthy donors. Expand
Detection of Epstein‐Barr virus DNA in American Burkitt's lymphoma
TLDR
It appears that EBV‐associated BL is inversely proportional to tumor endemicity, and an etiological role for EBV in BL remains speculative. Expand
Demonstration of two distinct components in the early antigen complex of epstein‐barr virus‐infected cells
TLDR
Comparative serum titration on acetone and ethanol‐fixed Raji‐EBV cell smears revealed that the transitory anti‐EA response observed in many IM patients was restricted almost exclusively to anti‐D, whereas such sera from NPC or BL patients usually gave positive reactions which in part, however, failed to conform with the R pattern. Expand
Relationship between the Epstein‐Barr virus genome and nasopharyngeal carcinoma in Caucasian patients
TLDR
The uniqueness and regularity of the association between EBV‐DNA and undifferentiated NPC extends over geographical barriers and holds true not only in the previously studied, moderate‐incidence African ethnic group, but also in the low-incidence Western patients. Expand
Primary epstein‐barr virus infections in African infants. II. Clinical and serological observations during seroconversion
TLDR
Of 27 Ghanaian infants examined monthly for the first 15 months of life and once more at 21 months, 12 acquired primary EBV infections by the age of 1 year and 9 others seroconverted during the subsequent period of observation, suggesting a low degree of viral excretion during silent seroconversions. Expand
Epstein‐Barr virus‐associated complement‐fixing and nuclear antigens in Burkitt lymphoma biopsies
TLDR
It is concluded that cells of BL biopsies may contain EBNA in addition to the EBV‐related membrane antigen previously described, providing further evidence that BL cells from African patients resemble non‐producer lymphoblastoid cell lines in containing EBNA and therefore appear to be transformed by EBV. Expand
Primary infection with Epstein-Barr virus in infants in the United States: clinical and serologic observations.
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American infants presenting with minor infectious complaints were studied serologically and 10 had antibodies to the early antigen complex induced by Epstein-Barr virus; however, these antibodies were directed, as in the Ghanaian infants, against the restricted rather than the diffuse components, in contrast to the pattern generally observed in infectious mononucleosis. Expand
Primary epstein‐barr virus infections in african infants. I. Decline of maternal antibodies and time of infection
TLDR
Infants from families of the lowest socio‐economic level tended to become infected somewhat earlier than those from better situated families but no other factors, such as household size or crowding, seemed to be associated with enhanced risk of early infection. Expand
Demonstration of epstein‐barr virus‐associated nuclear antigen in nasopharyngeal carcinoma cells from fresh biopsies
TLDR
The results confirm and extend previous reports that the carcinoma cells harbor EBV genomes and are confirmed to be free of antibodies to other nuclear antigens. Expand
Relationship between Epstein‐Barr virus (EBV) DNA and the EBV‐determined nuclear antigen (EBNA) in Burkitt lymphoma biopsies and other lymphoproliferative malignancies
TLDR
It is concluded that the virus does not really travel along with malignant lymphomas as a passenger in the seropositive patients, and the EBNA antigen test appears a relatively simple way of testing for the presence of the virus genome, provided it is carried out with appropriate controls. Expand
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