EPA guidance on the early detection of clinical high risk states of psychoses

  title={EPA guidance on the early detection of clinical high risk states of psychoses},
  author={Frauke Schultze-Lutter and Chantal Michel and S. Schmidt and B. G. Schimmelmann and Nadja P. Maric and Raimo K. R. Salokangas and Anita Riecher-R{\"o}ssler and Mark van der Gaag and Merete Nordentoft and Andrea Raballo and Anna Meneghelli and Max Marshall and Anthony P Morrison and Stephan Ruhrmann and Joachim Klosterk{\"o}tter},
  journal={European Psychiatry},
  pages={405 - 416}
Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A Meta-analytical Stratification.
There is meta-analytical evidence that BLIPS represents separate risk subgroup compared with the APS and GRD and there was no evidence that the GRD subgroup has a higher risk of psychosis than the CHR- subgroup.
Prediction of conversion to psychosis in individuals with an at-risk mental state: a brief update on recent developments
Purpose of review So far, only little more than one-third of individuals classified as being at-risk for psychosis have been shown to actually convert to frank psychosis during follow-up. There have
Course of clinical high-risk states for psychosis beyond conversion
During follow-up, CHR symptoms remitted in one-third of initially CHR-positive patients, while almost 10% met CHR criteria newly in CHR-negative adults presenting at early detection services, suggesting the presence of CHR criteria seems to maintain the risk for lower functioning and mental disorders, particularly for affective disorders.
Prediction of transition to psychosis in patients with a clinical high risk for psychosis: a systematic review of methodology and reporting
Most published models are probably overfitted and their reported predictive accuracy is likely to be overoptimistic, according to a systematic review of studies developing or validating multivariable clinical prediction models.
Clinical trajectories in the ultra-high risk for psychosis population
Adolescents at ultra-high risk of psychosis in Italian neuropsychiatry services: prevalence, psychopathology and transition rate
Given the uncertain outcome of UHR adolescents, future research is needed to determine whether the combined assessment of BS with UHR symptoms can improve the accuracy of psychosis prediction in adolescence.
Prevalence, course and psychosis-predictive value of negative symptoms in 22q11.2 deletion syndrome


Ultra high risk (UHR) for psychosis criteria: Are there different levels of risk for transition to psychosis?
Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study.
A differential predictive clinical model of transition to first-episode psychosis is developed that identified an increased risk of psychosis with appropriate prognostic accuracy in a sample of help-seeking patients.
Baseline differences in clinical symptomatology between ultra high risk subjects with and without a transition to psychosis
Identification of young people at risk of psychosis: validation of Personal Assessment and Crisis Evaluation Clinic intake criteria.
The results suggest that it is possible to accurately identify young people at imminent risk of psychosis within a short follow-up period and may lead the way to the development of preventive interventions for the ultra-high risk group.
The Significance of At-Risk Symptoms for Psychosis in Children and Adolescents
A preliminary rationale for how to deal with at-risk symptoms for psychosis in clinical practice is provided and it is suggested that attenuated psychotic symptoms and brief limited intermittent psychotic symptoms may be predictive of conversion to psychosis in help-seeking young adolescents.
Transition and remission in adolescents at ultra-high risk for psychosis
Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America.
These findings demonstrate that prospective ascertainment of individuals at risk for psychosis is feasible, with a level of predictive accuracy comparable to that in other areas of preventive medicine.