EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway.

@article{George2007EP4MP,
  title={EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway.},
  author={Robert J. George and Mark A Sturmoski and Shrikant Anant and Courtney W. Houchen},
  journal={Prostaglandins & other lipid mediators},
  year={2007},
  volume={83 1-2},
  pages={112-20}
}
The anti-apoptotic effect of PGE(2) was examined in Jurkat cells (human T-cell leukemia) by incubation with PGE(2) (5 nM) prior to treatment with the cancer chemotherapeutic agent camptothecin. Apoptosis was evaluated by caspase-3 activity in cell extracts and flow cytometry of propidium iodide-labeled cells. Pre-incubation with PGE(2) reduced camptothecin-induced caspase activity by 30% and apoptosis by 35%, respectively. Pharmacological data demonstrate that the EP4 receptor is responsible… CONTINUE READING
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