EP300--a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas.

@article{Mees2010EP300aMM,
  title={EP300--a miRNA-regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreas.},
  author={Soeren Torge Mees and Wolf Arif Mardin and Claudia Wendel and Nicole B{\"a}umer and Edith Willscher and Norbert Senninger and Christina Schleicher and Mario Colombo-Benkmann and J{\"o}rg Haier},
  journal={International journal of cancer},
  year={2010},
  volume={126 1},
  pages={114-24}
}
Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDACs) are well known. This study investigates genetic and epigenetic data together with tumor biology to find specific alterations responsible for metastasis formation. Using 16 human PDAC cell lines in a murine orthotopic PDAC model, local infiltration and metastatic spread were assessed by standardized dissemination scores. The cell lines were further classified into 3 hierarchical groups according to… CONTINUE READING
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