ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism.

@article{Pech2012ENaCIS,
  title={ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism.},
  author={Vladim{\'i}r Pech and Monika Thumov{\'a} and Young Hee Kim and Diana Agazatian and Edith Hummler and Bernard C Rossier and Alan M. Weinstein and Masayoshi Nanami and Susan M. Wall},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={303 1},
  pages={
          F45-55
        }
}
In cortical collecting ducts (CCDs) perfused in vitro, inhibiting the epithelial Na(+) channel (ENaC) reduces Cl(-) absorption. Since ENaC does not transport Cl(-), the purpose of this study was to determine how ENaC modulates Cl(-) absorption. Thus, Cl(-) absorption was measured in CCDs perfused in vitro that were taken from mice given aldosterone for 7 days. In wild-type mice, we observed no effect of luminal hydrochlorothiazide on either Cl(-) absorption or transepithelial voltage (V(T… CONTINUE READING

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