ENZYMATIC N‐METHYLATION OF INDOLEAMINES BY MAMMALIAN BRAIN: FACT OR ARTEFACT?

@article{Gomes1976ENZYMATICNO,
  title={ENZYMATIC N‐METHYLATION OF INDOLEAMINES BY MAMMALIAN BRAIN: FACT OR ARTEFACT?},
  author={U R Gomes and A. C. Neethling and BrianC. Shanley},
  journal={Journal of Neurochemistry},
  year={1976},
  volume={27}
}
Abstract— Indoleamine‐N‐methyltransferase (INMT) activity in brain and other tissues from various species was investigated. Using conventional radiochemical assay techniques it was found that apparent INMT activity in brain was linear with time and concentration of protein, indoleamine substrate and methyl donor (S‐adenosylmethionine). However, examination of the reaction products by means of exhaustive thin‐layer chromatographic analysis failed to reveal evidence of significant N‐methylation… Expand
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