ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells.

@article{Bacci2009ENPP1QV,
  title={ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells.},
  author={Simonetta Bacci and R Di Paola and Claudia Menzaghi and Patrizia Di Fulvio and Sara Di Silvestre and Francesco Pellegrini and Roberto Baratta and Antonella Marucci and Sandra Mastroianno and Grazia Fini and Gloria Formoso and Agostino Consoli and Francesco Perticone and Lucia Frittitta and Assunta Pandolfi and Vincenzo Trischitta},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2009},
  volume={29 10},
  pages={
          1678-83
        }
}
OBJECTIVE Insulin resistance induces increased pulse pressure (PP), endothelial dysfunction (ED), and reduced bioavailability of endothelium-derived nitric oxide (NO). The genetic background of these 3 cardiovascular risk factors might be partly common. The ENPP1 K121Q polymorphism is associated with insulin resistance and cardiovascular risk. METHODS AND RESULTS We investigated whether the K121Q polymorphism is associated with increased PP in white Caucasians and with ED in vitro. In 985… CONTINUE READING

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