ENOXACIN RAISES PLASMA THEOPHYLLINE CONCENTRATIONS

@article{Wijnands1984ENOXACINRP,
  title={ENOXACIN RAISES PLASMA THEOPHYLLINE CONCENTRATIONS},
  author={W. J. A. Wijnands and C. L. A. Herwaarden and Tom B. Vree},
  journal={The Lancet},
  year={1984},
  volume={324},
  pages={108-109}
}
Effect of norfloxacin on theophylline metabolism
TLDR
It is concluded that norfloxacin taken in recommended doses for 3 days has a small inhibitory effect on theophylline metabolism that would probably not cause clinically important elevations in theophyLLine concentrations in most patients.
The influence of quinolone derivatives on theophylline clearance.
TLDR
There is growing evidence that the observed interaction is caused not by the parent drugs, but by the 4-oxo metabolite of enoxacin, pefloxac in and ciprofloxACin and nalidixic acid.
Interaction Between Quinolones and Caffeine
TLDR
Caffeine should be avoided in patients with liver disorders, cardiac arrhythmias, latent epilepsy or in intensive care while undergoing treatment with enoxacin or ciprofloxac in order to facilitate the elimination of caffeine.
Lack of interaction between lomefloxacin and caffeine in normal volunteers
TLDR
It is concluded that lomefloxacin has no significant effect on the disposition of caffeine in young healthy volunteers and the frequencies of central nervous system-related effects for the two treatments were not statistically different.
Effect of quinolones on caffeine disposition
TLDR
There was a decline in caffeine metabolite levels in the 24‐hour urine samples for both quinolone treatments, suggesting that pipemidic acid and, to a lesser degree, norfloxacin inhibit metabolism of the N‐demethylation pathways of caffeine.
Pharmacokinetic Interactions Between Theophylline and Other Medication (Part II)
SummaryPart I of this article, which appeared in the previous issue of the Journal, covered the effects or lack of effects on theophylline clearance of sympathomimetics, corticosteroids,
Safety of fleroxacin coadministered with theophylline to young and elderly volunteers
TLDR
It is concluded that fleroxacin may be administered concomitantly with theophylline in either young or elderly patients, particularly in patients with chronic obstructive pulmonary disease, for whom data are currently lacking.
Pharmacokinetic determination of relative potency of quinolone inhibition of caffeine disposition
TLDR
A simple pharmacokinetic model for the caffeine-quinolone interaction was developed, which provides a unified method for evaluation and comparison of the effect of quinolones on the disposition of caffeine.
Enoxacin — a potent inhibitor of theophylline metabolism
TLDR
Unexpectedly, the renal clearance of theophylline metabolites was found to be drastically reduced when enoxacin was coadministered, which led to unchanged or even to elevated plasma levels of the metabolites.
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References

In vitro activity of CI-919 (AT-2266), an oral antipseudomonal compound.
TLDR
CI-919 may be useful as an oral antibiotic for the treatment of infections due to diverse bacteria, including P. aeruginosa, and was bactericidal for most isolates, showing no cross-resistance with unrelated antimicrobial agents.