ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Somatostatin Receptor Imaging with 111In-Pentetreotide

@article{Kwekkeboom2009ENETSCG,
  title={ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Somatostatin Receptor Imaging with 111In-Pentetreotide},
  author={Dik J. Kwekkeboom and Eric Paul Krenning and Klemens Scheidhauer and V Lewington and Rachida Lebtahi and Ashley B Grossman and Pavel V{\'i}tek and Anders Sundin and U. Pl{\"o}ckinger},
  journal={Neuroendocrinology},
  year={2009},
  volume={90},
  pages={184 - 189}
}
ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors : Somatostatin Receptor Imaging with In-111-Pentetreotide 
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TLDR
The aim of this paper was to analyse the importance of tumour volume and growth for the visualization by SSTR scintigraphy of metastases from medullary thyroid carcinoma (MTC).
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TLDR
Somatostatin receptor expression was demonstrated by in vivo imaging with (111)In-pentetreotide in three patients, which adds another imaging technique to the nuclear medicine armamentarium for detecting recurrent and metastatic cancer in patients with Hürthle cell cancer.
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SPECT with Tc-99m depreotide is highly accurate in this clinical setting and may be preferable to FDG-PET because of its lower cost and wider availability.
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Satostatin receptor scintigraphy improves tumor detection, has major clinical significance and should be performed systematically for staging and therapeutic decision making in patients with GEP tumors.
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It is concluded that somatostatin receptor scintigraphy using [111In-DTPA-D-Phe1]-octreotide has a future role in the staging of patients with carcinoid disease.
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This research presents a novel and scalable approach to regenerative medicine that addresses the underlying cause of central giant cell granuloma, which is a leading cause of cancer in women.
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TLDR
In patients with the Zollinger-Ellison syndrome, somatostatin receptor scintigraphy appeared to be a useful new addition to the battery of tests used for tumour detection.
Specificity of somatostatin receptor scintigraphy: a prospective study and effects of false-positive localizations on management in patients with gastrinomas.
TLDR
False-positive SRS localization occurs in 1 of 10 patients with ZES, and the percentage of patients in whom false-positive localization results in altered management can be reduced to below 3% and the correct diagnosis made in almost every case.
Somatostatin Receptor Scintigraphy: Its Sensitivity Compared with That of Other Imaging Methods in Detecting Primary and Metastatic Gastrinomas: A Prospective Study
TLDR
It is difficult for the practitioner to define the potential role of somatostatin receptor scintigraphy in the evaluation of a patient with a gastroenteropancreatic syndrome because many studies do not provide the data needed and it remains unclear whether additional localization studies are helpful.
Clinical impact of somatostatin receptor scintigraphy in the management of paragangliomas of the head and neck.
TLDR
Because of very high sensitivity in detecting paraganglioma, SRS should be included in a multiple-step strategy for patients' management and could be useful in ruling out the diagnosis of schwannoma.
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