Corpus ID: 53488080

ENDOCRINOLOGY 2-[ 18 F ]-fluoro-2-deoxy-D-glucose positron emission tomography / computed tomography in differentiated thyroid carcinoma : clinical indications and controversies in diagnosis and follow-up

  title={ENDOCRINOLOGY 2-[ 18 F ]-fluoro-2-deoxy-D-glucose positron emission tomography / computed tomography in differentiated thyroid carcinoma : clinical indications and controversies in diagnosis and follow-up},
  author={Massimo Salvatori and Bernadette Biondi and Vittoria Rufini},
In recent years, 2-[F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has emerged as an important tool for the postoperative management of patients with differentiated thyroid cancer (DTC) and it is widely used in selected clinical situations. The most valuable role that FDG-PET/CT plays in clinical practice is that it can be used to obtain prognostic information in patients with increasing thyroglobulin (Tg) levels and negative I whole-body scan post… Expand
3 Citations

Figures and Tables from this paper

Optimal threshold of stimulated serum thyroglobulin level for 18F-FDG PET/CT imaging in patients with thyroid cancer
This study was to explore the optimal threshold of thyroid-stimulating hormone (TSH)-stimulated serum thyroglobulin (s-Tg) for patients who were to receive 18F-fluorodeoxyglucose (18F-FDG) PET/CTExpand
68 Ga-PSMA PET / CT in staging and restaging of Prostate Cancer Patients : comparative study with 18 F-Choline PET / CT
Comparison of detection rate between PSMA and 18F-fluoromethylcholine (FCH) PET/CT scan in pre or post-op prostate cancer patients revealed no appreciable difference in the tracer intensity of the detected bony lesions in each modality. Expand
Guía de manejo del nódulo tiroideo y del cáncer diferenciado de tiroides de la Sociedad Mexicana de Oncología
The GICC-SMeO y Alberto Tavares-de the Paz representan el Grupo de Investigación en Cáncer de Cabeza y Cuello de la Sociedad Mexicana de Oncología. Expand


Real-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning.
FDG-PET scanning is a simple, expensive, but powerful means to restage thyroid cancer patients who develop subsequent metastases, assigning them to groups that are either at low ( FDG negative) or high (FDG positive) risk of cancer-associated mortality. Expand
Feasibility and benefit of fluorine 18-fluoro-2-deoxyglucose-guided surgery in the management of radioiodine-negative differentiated thyroid carcinoma metastases.
These results show the feasibility and benefit of (18)F-FDG radio-guided surgery with a gamma probe in the management of differentiated thyroid cancer patients with radioiodine-negative recurrence. Expand
Does recombinant human thyrotropin-stimulated positron emission tomography with [18F]fluoro-2-deoxy-D-glucose improve detection of recurrence of well-differentiated thyroid carcinoma in patients with low serum thyroglobulin?
In the diagnosis of recurrent disease in patients with differentiated thyroid carcinoma and low Tg level, the sensitivity of rhTSH-stimulated PET/CT-FDG seems to be low and no correlation was observed between PET/ CT- FDG findings and TG level. Expand
Implication of 2-18fluor-2-deoxyglucose positron emission tomography in the follow-up of Hürthle cell thyroid cancer.
This study supports the efficiency of FDG-PET in the follow-up of HTC by revealing an overall sensitivity of 92, a specificity of 80, a positive predictive value of 92%, and a negative predictivevalue of 80% while the accuracy was 89%. Expand
Value of 18F-FDG-PET/PET-CT in differentiated thyroid carcinoma with radioiodine-negative whole-body scan: a meta-analysis
FDG-PET is especially effective in detecting patients with elevated thyroglobulin levels and normal radioiodine WBS; FDG- PET/CT is a more sensitive method in the follow-up of thyroid cancer recurrence or metastases, particularly in those with negative WBS. Expand
Assessment of the incremental value of recombinant thyrotropin stimulation before 2-[18F]-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography imaging to localize residual differentiated thyroid cancer.
The use of rhTSH for 2-[18F]-fluoro-2-deoxy-D-glucose-PET/CT significantly increased the number of lesions detected, but the numbers of patients in whom any lesion was detected were no different between basal and rh TSH-stimulated PET/CT scans. Expand
The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery.
Patients at a high risk of distant metastasis may benefit from PET before surgery, and factors associated with FDG positivity are related to a poor prognosis; therefore, FDG PET scans before surgery may facilitate the prediction of the prognosis of differentiated thyroid cancer. Expand
Relationship between the immunohistochemistry of the primary tumour and 18F-FDG-PET/CT at recurrence in patients with well-differentiated thyroid carcinoma
Investigation of the immunochemical profile of the primary tumour for thyroid carcinoma failed to confirm the preliminary results of Hooft and colleagues and immunochemistry does not appear to be a definitive tool for predicting the results of 18F-FDG-PET/CT in cases of recurrence. Expand
Diagnostic accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in differentiated thyroid cancer patients with elevated thyroglobulin and negative 131I whole body scan: evaluation by thyroglobulin level
18F-FDG PET/CT is useful in detection and localization of recurrent thyroid cancer in patients with negative diagnostic radioiodine scan despite elevated Tg greater than 20 ng/ml or high anti-Tg Ab titers, which may vary depending on serum Tg levels at imaging. Expand
The role of TSH for 18F-FDG-PET in the diagnosis of recurrence and metastases of differentiated thyroid carcinoma with elevated thyroglobulin and negative scan: a meta-analysis.
The data indicate that TSH stimulation should be recommended for DTC patients undergoing PET scanning in these circumstances, however, further well-designed studies emphasizing on the clinical significance of altered management by PET under T SH stimulation are needed. Expand