ENDOCRINE TUMOURS: Calcitonin in thyroid and extra-thyroid Neuroendocrine Neoplasms: the two-faced Janus.

  title={ENDOCRINE TUMOURS: Calcitonin in thyroid and extra-thyroid Neuroendocrine Neoplasms: the two-faced Janus.},
  author={Elisa Giannetta and Valentina Guarnotta and Barbara Altieri and Concetta Sciammarella and Elia Guadagno and Pasqualino Malandrino and Giulia Puliani and Tiziana Feola and Andrea M. Isidori and Annamaria Colao and Antongiulio Faggiano},
  journal={European journal of endocrinology},
An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescent assays with high sensitivity and specificity; however, slightly-moderately elevated levels could be attributable to various confounding factors. Calcitonin values >100 pg/mL are… 

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