ENDOCRINE TUMOURS: Calcitonin in thyroid and extra-thyroid Neuroendocrine Neoplasms: the two-faced Janus.

@article{Giannetta2020ENDOCRINETC,
  title={ENDOCRINE TUMOURS: Calcitonin in thyroid and extra-thyroid Neuroendocrine Neoplasms: the two-faced Janus.},
  author={Elisa Giannetta and Valentina Guarnotta and Barbara Altieri and Concetta Sciammarella and Elia Guadagno and Pasqualino Malandrino and Giulia Puliani and Tiziana Feola and Andrea M. Isidori and Annamaria Colao and Antongiulio Faggiano},
  journal={European journal of endocrinology},
  year={2020}
}
An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescent assays with high sensitivity and specificity; however, slightly-moderately elevated levels could be attributable to various confounding factors. Calcitonin values >100 pg/mL are… 

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References

SHOWING 1-10 OF 142 REFERENCES
Differential diagnosis of calcitonin-secreting neuroendocrine carcinoma of the foregut by pentagastrin stimulation
TLDR
Irrespective of the pathophysiological background, pentagastrin stimulation affords a differential diagnosis in neuroendocrine carcinoma of the foregut when chronic renal failure is excluded.
Calcitonin-Producing Neuroendocrine Neoplasms of the Pancreas: Clinicopathological Study of 25 Cases and Review of the Literature
TLDR
Cal-IR PanNENs did not show any significant difference with the whole series of neoplasms included in the study, when the clinicopathological parameters were considered, except for a younger age at diagnosis and for a larger size of the tumor in non-functioning Cal- IR PanN ENs.
Interpretation of serum calcitonin in patients with chronic autoimmune thyroiditis.
TLDR
Patients with hypercalcitoninemia suffering from chronic autoimmune thyroiditis should undergo the same clinical evaluation procedure as patients do without thyroid autoimmunity.
Early diagnosis of medullary thyroid cancer: Are calcitonin stimulation tests still indicated in the era of highly sensitive calcitonin immunoassays?
TLDR
Predefined sex-specific bCT cut-off levels are helpful for the early detection of MTC and for predicting lateral neck lymph node metastasis.
Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter
TLDR
It is emphasized that marked hypercalcitoninemia in the presence of thyroid nodules is not necessarily due to medullary thyroid carcinoma; awareness of this could avoid unnecessary thyroidectomy, and the prevalence of calcitonin-secreting pancreatic tumors is underestimated.
Neuroendocrine tumors producing calcitonin: characteristics, prognosis and potential interest of calcitonin monitoring during follow-up.
TLDR
Serum CT levels may be raised in some patients with NETs, especially from foregut origin, and of high grade, and the suggested value of CT monitoring during follow-up must be confirmed in further studies.
Association of Basal and Calcium-stimulated Calcitonin Levels with Pathological Findings After Total Thyroidectomy.
TLDR
The overlap of calcitonin levels between MTC and CCH reduces the accuracy of the calcium stimulation test, and an appreciable number of patients with psCT levels >100 pg/ml harbor differentiated thyroid carcinoma of follicular origin.
Ectopic calcitonin secretion in a woman with large cell neuroendocrine lung carcinoma
TLDR
A 47-year old woman with Hashimoto thyroiditis, goiter, cervical lymphadenopathy and high CT and CEA levels is presented with LCNEC, a condition which is usually observed in older men (7th decade) and is not associated with CT secretion.
Medullary thyroid carcinoma and duodenal calcitonin-secreting neuroendocrine tumour: more than coincidence?
TLDR
A patient, a 63-year-old female, who was diagnosed with a medullary thyroid carcinoma (MTC), but whose circulating calcitonin levels remained elevated after thyroidectomy with no evidence of metastatic disease is described, which is the first identification of a duodenal NET secreting calciton in a patient with MTC.
Calcitonin negative Medullary Thyroid Carcinoma: a challenging diagnosis or a medical dilemma?
TLDR
Calcitonin negative medullary thyroid carcinoma is an extremely rare pathology and the diagnosis and the surveillance is often challenging and delayed, due to the lack of elevation of serum markers as calcitonin and carcinoembryionic antigen.
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