Corpus ID: 99008420

ENANTIOSELECTIVE SYNTHESIS AND CYCLOISOMERIZATION OF 1-BICYCLO[1.1.0]BUTAN-1-YL ALKYLAMINES

@inproceedings{Yan2016ENANTIOSELECTIVESA,
  title={ENANTIOSELECTIVE SYNTHESIS AND CYCLOISOMERIZATION OF 1-BICYCLO[1.1.0]BUTAN-1-YL ALKYLAMINES},
  author={Yongzhao Yan},
  year={2016}
}
This dissertation demonstrates the synthesis and application studies of 1-bicyclo[1.1.0]butyl alkylamines. The enantioselective synthesis of 1-bicyclo[1.1.0]butyl alkylamines was achieved by dicarbene addition to enantiomerically enriched propargyl amides. The enantioselective addition of alkynes to imines proceeded well for most N-DPP amides. But the carbene addition suffered from the formation of cyclopropane byproducts. However, a series of silyl-substituted bicyclo[1.1.0]butanes could be… Expand

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