EMT transcription factors: implication in osteosarcoma.

  title={EMT transcription factors: implication in osteosarcoma.},
  author={Guoqiong Yang and Jian Yuan and Kanghua Li},
  journal={Medical oncology},
  volume={30 4},
The primary malignant bone tumor, osteosarcoma, is a deadly disorder. Its etiology is complex, and treatment is mostly obscure. The transcription factors (TFs) involved in epithelial to mesenchymal transition (EMT) have significant role in osteosarcoma. A number of evidence suggests that overexpression of EMT-TFs, such as Twist, Snails and Zebs, is involved in complex pathogenesis of osteosarcoma. Recent research studies have showed some extent of promise in osteosarcoma treatment by targeting… CONTINUE READING

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