EMT circulating tumor cells detected by cell-surface vimentin are associated with prostate cancer progression

@inproceedings{Satelli2017EMTCT,
  title={EMT circulating tumor cells detected by cell-surface vimentin are associated with prostate cancer progression},
  author={Arun Satelli and Izhar Singh Batth and Zachary Brownlee and Abhishek Mitra and Shouhao Zhou and Hyangsoon Noh and Christina R. Rojas and Heming Li and Qing H Meng and Shulin Li},
  booktitle={Oncotarget},
  year={2017}
}
Recent advances in the field of circulating tumor cells (CTC) have shown promise in this liquid biopsy-based prognosis of patient outcome. However, not all of the circulating cells are tumor cells, as evidenced by a lack of tumor-specific markers. The current FDA standard for capturing CTCs (CellSearch) relies on an epithelial marker and cells captured via CellSearch cannot be considered to have undergone EMT. Therefore, it is difficult to ascertain the presence and relevance of any mesenchymal… CONTINUE READING
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