EMT blockage strategies: Targeting Akt dependent mechanisms for breast cancer metastatic behaviour modulation.

@article{Rafael2015EMTBS,
  title={EMT blockage strategies: Targeting Akt dependent mechanisms for breast cancer metastatic behaviour modulation.},
  author={Dor Rafael and Slavom{\'i}ra Doktorovov{\'a} and Helena F. Florindo and Petra Gener and Ibane Abasolo and Sarit Schwartz and Mafalda Ascens{\~a}o Videira},
  journal={Current gene therapy},
  year={2015},
  volume={15 3},
  pages={
          300-12
        }
}
Epithelial Mesenchymal Transition (EMT) is an event where epithelial cells acquire mesenchymal-like phenotype. EMT can occur as a physiological phenomenon during tissue development and wound healing, but most importantly, EMT can confer highly invasive properties to epithelial carcinoma cells. The impairment of E-cadherin expression, an essential cell-cell adhesion protein, together with an increase in the expression of mesenchymal markers, such as N-cadherin, vimentin, and fibronectin… CONTINUE READING
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