EMT-associated up-regulation of L1CAM provides insights into L1CAM-mediated integrin signalling and NF-κB activation.

@article{Kiefel2012EMTassociatedUO,
  title={EMT-associated up-regulation of L1CAM provides insights into L1CAM-mediated integrin signalling and NF-κB activation.},
  author={Helena Kiefel and Sandra Bondong and Marco Pfeifer and Uwe Schirmer and Natalie Erbe-Hoffmann and Heiner Sch{\"a}fer and Susanne Sebens and Peter Altevogt},
  journal={Carcinogenesis},
  year={2012},
  volume={33 10},
  pages={1919-29}
}
Expression of L1 cell adhesion molecule (L1CAM) is associated with poor prognosis in a variety of human carcinomas including breast, ovarian and pancreatic ductal adenocarcinoma (PDAC). Recently we reported that L1CAM induces sustained nuclear factor kappa B (NF-κB) activation by augmenting the autocrine production of interleukin 1 beta (IL-1β), a process dependent on interaction of L1CAM with integrins. In the present study, we demonstrate that transforming growth factor β1 (TGF-β1) treatment… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NFκB activation

  • B Bondong
  • Ann Oncol
  • 2011

Similar Papers

Loading similar papers…