EMT and tumor metastasis

@inproceedings{Heerboth2015EMTAT,
  title={EMT and tumor metastasis},
  author={Sarah Heerboth and Genevieve Housman and Meghan Leary and Mckenna Longacre and Shannon Byler and Karolina Lapinska and Amber Willbanks and Sibaji Sarkar},
  booktitle={Clinical and translational medicine},
  year={2015}
}
EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss the signaling pathways and the differential expression and down-regulation of receptors in both tumor cells and stromal cells, which play a… CONTINUE READING

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