EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes

@article{Jiang2012EMTAC,
  title={EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes},
  author={Rongrong Jiang and Yuan Li and Yuan Xu and Yun Zhou and Ying Pang and L i Sh{\'e}n and Yongxi Zhao and Jianping Zhang and Jianwei Zhou and Xinru Wang and Qizhan Liu},
  journal={Archives of Toxicology},
  year={2012},
  volume={87},
  pages={991-1000}
}
Exposure of humans to inorganic arsenic can cause skin cancer. The epithelial–mesenchymal transition (EMT) and acquisition of cancer stem cell (CSC)-like properties are essential steps in the initiation of human skin cancers; however, the mechanisms of action remain obscure. We have found that, during the neoplastic transformation induced by a low concentration (1.0 μM) of arsenite in human keratinocyte HaCaT cells, the cells undergo an EMT and then acquire a malignant CSC-like phenotype. With… CONTINUE READING
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