EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

@inproceedings{Morel2012EMTIC,
  title={EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice},
  author={Anne-Pierre Morel and George W. Hinkal and Cl{\'e}mence Thomas and Fr{\'e}d{\'e}rique Fauvet and St{\'e}phanie Courtois-Cox and Anne Wierinckx and Mojgan Devouassoux-Shisheboran and Isabelle 6 Treilleux and Agn{\`e}s Tissier and Baptiste Gras and Julie Pourchet and Isabelle Puisieux and Gareth J. Browne and Douglas B. Spicer and Jo{\"e}l Lachuer and St{\'e}phane Ansieau and Alain Puisieux},
  booktitle={PLoS genetics},
  year={2012}
}
The epithelial-mesenchymal transition (EMT) is an embryonic transdifferentiation process consisting of conversion of polarized epithelial cells to motile mesenchymal ones. EMT-inducing transcription factors are aberrantly expressed in multiple tumor types and are known to favor the metastatic dissemination process. Supporting oncogenic activity within primary lesions, the TWIST and ZEB proteins can prevent cells from undergoing oncogene-induced senescence and apoptosis by abolishing both p53… CONTINUE READING
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