EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.

@article{Alaminos2005EMP3AM,
  title={EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.},
  author={Miguel Alaminos and Ver{\'o}nica D{\'a}valos and Santiago Ropero and F. Setien and Maria Fe Paz and Michel Herranz and Mario F Fraga and J. Vivancos Mora and Nai-Kong V Cheung and William L. Gerald and Manel Esteller},
  journal={Cancer research},
  year={2005},
  volume={65 7},
  pages={2565-71}
}
The presence of common genomic deletions in the 19q13 chromosomal region in neuroblastomas and gliomas strongly suggests the presence of a putative tumor suppressor gene for these neoplasms in this region that, despite much effort, has not yet been identified. In an attempt to address this issue, we compared the expression profile of 89 neuroblastoma tumors with that of benign ganglioneuromas by microarray analysis. Probe sets (637 of 62,839) were significantly down-regulated in neuroblastoma… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

Promoter Hypermethylation of the EMP3 Gene in a Series of 229 Human Gliomas

BioMed research international • 2013
View 10 Excerpts
Highly Influenced

EMP3 Overexpression in Primary Breast Carcinomas is not Associated with Epigenetic Aberrations

Journal of Korean medical science • 2009
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 13 Excerpts
Highly Influenced

Neoplasms of the central nervous system.

The Practitioner • 1977
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…