EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF

@inproceedings{Khayati2015EMMPRINCD147IA,
  title={EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF},
  author={Farah Khayati and Laura Perez-Cano and Kamel Maouche and Aur{\'e}lie Sadoux and Zineb Boutalbi and Marie-Pierre Podgorniak and Uwe Maskos and Niclas Setterblad and Anne Janin and Fabien Calvo and Celeste Lebb{\'e} and Suzanne Menashi and Juan Fern{\'a}ndez-Recio and Samia Mourah},
  booktitle={Oncotarget},
  year={2015}
}
EMMPRIN/CD147 is mainly known for its protease inducing function but a role in promoting tumor angiogenesis has also been demonstrated. This study provides evidence that EMMPRIN is a new coreceptor for the VEGFR-2 tyrosine kinase receptor in both endothelial and tumor cells, as it directly interacts with it and regulates its activation by its VEGF ligand, signalling and functional consequences both in vitro and in vivo. Computational docking analyses and mutagenesis studies identified a… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Exosomes Derived from Embryonic Stem Cells as Potential Treatment for Cardiovascular Diseases.

  • Advances in experimental medicine and biology
  • 2017
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Up‐regulated basigin‐2 in microglia induced by hypoxia promotes retinal angiogenesis

  • Journal of cellular and molecular medicine
  • 2017
VIEW 2 EXCERPTS
CITES RESULTS

Molecular association of CD98, CD29, and CD147 critically mediates monocytic U937 cell adhesion

  • The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES