EML4-ALK translocation predicts better outcome in lung adenocarcinoma patients with wild-type EGFR.

@article{Wu2012EML4ALKTP,
  title={EML4-ALK translocation predicts better outcome in lung adenocarcinoma patients with wild-type EGFR.},
  author={Shang-Gin Wu and Yao-Wen Kuo and Yih-leong Chang and Jin-Yuan Shih and Ya-Hui Chen and Meng-Feng Tsai and Chong-Jen Yu and C J Yang and Pan-Chyr Yang},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2012},
  volume={7 1},
  pages={98-104}
}
INTRODUCTION The echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) fusion represents a novel target in a subset of non-small cell lung cancer, especially adenocarcinoma. EML4-ALK fusion is mutually exclusive with epidermal growth factor receptor (EGFR) mutations. To understand the impact of EML4-ALK on the prognosis of non-small cell lung cancer, we examined EML4-ALK fusion in lung adenocarcinoma from patients with wild-type EGFR and analyzed their clinical… CONTINUE READING
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