EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas.

@article{Shinmura2008EML4ALKFT,
  title={EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas.},
  author={Kazuya Shinmura and S. Kageyama and Hong Tao and Tomoyasu Bunai and Masaya Suzuki and Takaharu Kamo and Kazuya Takamochi and Kazuya Suzuki and Masayuki Tanahashi and Hiroshi Niwa and Hiroshi Ogawa and Haruhiko Sugimura},
  journal={Lung cancer},
  year={2008},
  volume={61 2},
  pages={163-9}
}
EML4-ALK gene fusions have recently been discovered in a subset of human lung carcinomas, and fusions of the ALK tyrosine kinase gene with the NPM, TPM3, CLTC, ATIC, and TFG genes have been found in hematological malignancies. To elucidate the role of fusions between ALK and other genes in pulmonary carcinogenesis, we examined 77 non-small cell lung carcinomas (NSCLCs) for EML4-, NPM-, TPM3-, CLTC-, ATIC-, and TFG-ALK fusion transcripts by RT-PCR and subsequent sequencing analysis. Although no… CONTINUE READING

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