EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers.

  title={EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers.},
  author={Yuichi Ishikawa and Kengo Takeuchi and Yuki Togashi and Kimie Nomura and Hironori Ninomiya and Michiyo Okui and Yukitoshi Satoh and Sakae Okumura and Ken Nakagawa and Manabu Soda and Young Lim Choi and T. Niki and Hiroyuki Mano},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  volume={3 1},
INTRODUCTION Very recently, we have found a novel fusion product between the echinoderm microtubule-associated protein-like4 (EML4) and the anaplastic lymphoma kinase (ALK) in non-small cell lung cancers (NSCLCs). Tumors featuring EML4-ALK fusion constitute one subtype of NSCLC that might be highly sensitive to ALK inhibitors. Herein, we present results of a first large scale study of EML4-ALK fusion in lung cancers. METHODS Using reverse transcription-polymerase chain reaction for EML4-ALK… CONTINUE READING
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