EMD638683, a novel SGK inhibitor with antihypertensive potency.

@article{Ackermann2011EMD638683AN,
  title={EMD638683, a novel SGK inhibitor with antihypertensive potency.},
  author={Teresa F. Ackermann and Krishna Murthy Boini and Norbert Beier and Wolfgang Scholz and Thomas Fuch\ss and Florian Lang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2011},
  volume={28 1},
  pages={137-46}
}
UNLABELLED The serum- and glucocorticoid-inducible kinase 1 (SGK1) is transcriptionally upregulated by mineralocorticoids and activated by insulin. The kinase enhances renal tubular Na(+)-reabsorption and accounts for blood pressure increase following high salt diet in mice made hyperinsulinemic by dietary fructose or fat. The present study describes the in vitro and in vivo efficacy of a novel SGK1 inhibitor (EMD638683). EMD638683 was tested in vitro by determination of SGK1-dependent… CONTINUE READING