EMD 52692 (bimakalim), a new potassium channel opener, attenuates luminol-enhanced chemiluminescence and superoxide anion radical formation by zymosan-activated polymorphonuclear leukocytes.

@article{Pieper1992EMD5,
  title={EMD 52692 (bimakalim), a new potassium channel opener, attenuates luminol-enhanced chemiluminescence and superoxide anion radical formation by zymosan-activated polymorphonuclear leukocytes.},
  author={Galen M. Pieper and Garrett John Gross},
  journal={Immunopharmacology},
  year={1992},
  volume={23 3},
  pages={
          191-7
        }
}
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The Small G-protein Rac Mediates Depolarization-induced Superoxide Formation in Human Endothelial Cells*

It is concluded that depolarization is an important stimulus of endothelial superoxide production, which involves a tyrosine phosphorylation-dependent translocation of the small G-protein Rac.

Adenosine inhibition of neutrophil damage during reperfusion does not involve KATP-channel activation.

It is concluded that adenosine A2 activation before reperfusion partially reduces infarct size by inhibiting neutrophil activity and that this effect does not involve KATP-channel stimulation.

Isoflurane Inhibits Neutrophil-Endothelium Interactions in the Coronary Circulation: Lack of a Role for Adenosine Triphosphate-Sensitive Potassium Channels

Isoflurane had an inhibitory action on neutrophil-endothelium interactions and neutrophils-mediated coronary endothelial dysfunction—effects that may be involved in its cardioprotective action in vivo.

Depolarization-associated iron release with abrupt reduction in pulmonary endothelial shear stress in situ.

ROS generation and iron release with ischemia are independent although both are subsequent to endothelial cell membrane depolarization, indicating that ROS generation is not required for ischemic-mediated iron release.

Influence of ion channel modulation on in vitro interferon-gamma induced MHC class I and II expression on macrophages.

The in vitro effect of K+ channel blockers quinidine and verapamil, anion channel blocker SITS and K+ channel openers diazoxide, pinacidil, and BRL 38227 on interferon-gamma (IFN-gamma) induced MHC…

Plasmolemmal potassium gradient does not affect lung protection by an ATP-regulated potassium channel opener.

Role for NADPH/NADH Oxidase in the Modulation of Vascular Tone a

Under all conditions of an activated circulating and/or local renin‐angiotensin system endothelial dysfunction secondary to increased vascular O2−• production is expected, and dynamic interactions may likely have important implications for tissue perfusion and the process of atherosclerosis.

Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs.

Results indicate that myocardial preconditioning in the canine heart produced by a short period of ischemia or a KATP channel opener is not mediated by an increase inAdenosine release, as measured by coronary venous adenosine concentrations, during 60 minutes of occlusion or the initial 30 minutes of reperfusion.

Oxidant generation with K(+)-induced depolarization in the isolated perfused lung.

Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.

It is suggested that KATP openers would maintain the mitochondrial respiratory function during lung preservation, prevent lipid peroxidation after reperfusion, and attenuate ischemia-reperfusion injury.

References

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