EMAS position statement: Predictors of premature and early natural menopause.

  title={EMAS position statement: Predictors of premature and early natural menopause.},
  author={Gita Devi Mishra and Hsin-Fang Chung and Antonio Cano and Peter Chedraui and Dimitrios G. Goulis and Patrice Lop{\`e}s and Alfred Otto Mueck and Margaret C. P. Rees and Levent Mehmet Senturk and Tommaso Simoncini and John C Stevenson and Petra Stute and Pauliina Tuomikoski and Irene Lambrinoudaki},

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Prevalence and Risk Factors of Premature Ovarian Insufficiency/Early Menopause.

Understanding and clarification of these risk factors will facilitate prevention and risk minimization strategies to optimize women's health and establish a causal role and the underlying mechanisms remains elusive.


It is found that earlier cessation of menstruation is influenced by circumstances at birth, and smoking is positively correlated with early menopause, while regular exercise and moderate frequency of alcohol drinking in women's early thirties are associated with a reduced risk of earlyMenopause.

Age of Natural Menopause Among Jordanian Women and Factors Related to Premature and Early Menopause

Smoking is the main contributor of premature/early menopause in Jordanian women and increased awareness and public health policy about the adverse effects of smoking on women’s reproductive health are needed.

Association of oral contraceptives and tubal ligation with risk of early natural menopause.

The findings do not support any material hazard or benefit for the use of OCs or tubal ligation, and TL was associated with a modestly higher risk of early menopause.

Diet, menopause, and risk of hormone-related cancers

This work has demonstrated for the first time, how diet can play a role in influencing age at natural menopause in the UK, and further evidence for an association between diet and the presence of VMS and the risk of hormone-related cancers was provided.

Can time to menopause be predicted?

There are as of now no reliable ways of predicting when a woman will enter menopause, with the exception of anti‐Müllerian hormone measurements, either alone or in combination with chronological age close toMenopause.

Premature ovarian insufficiency: an International Menopause Society White Paper

It is hoped that a global task force will be convened in order to formulate a consensus statement across key societies, to accelerate date collection and analysis of a global POI registry, and to facilitate progress in the key defined areas of research.

The Relationship Between Genetic Variants Associated with Premature Menopause and Lipid Profile in Women Recruited from MASHAD Cohort Study

Some SNPs reported to be associated with PM appear to be independently associated with dyslipidemia, which may be helpful to identify subjects with PM who may be susceptible to CVD.

Early Menopause May Associate With a Higher Risk of CKD and All-Cause Mortality in Postmenopausal Women: An Analysis of NHANES, 1999–2014

Both early natural and surgical menopause were associated with a higher risk of Chronic kidney disease in post-menopausal women, and both were a hazard factor for survival in the non-CKD group, but not in the CKD group.

Premature menopause among women in India: Evidence from National Family Health Survey‐IV

This study attempted to determine the prevalence and factors associated with premature menopause among 302 557 women aged 25–39 years in India.



Long-term health consequences of premature or early menopause and considerations for management

It is important to individualize hormone therapy for women with early estrogen deficiency, and higher dosages may be needed to approximate physiological concentrations found in premenopausal women.

Early menarche, nulliparity and the risk for premature and early natural menopause

The findings support early monitoring of women with early menarche, especially those who have no children, for preventive health interventions aimed at mitigating the risk of adverse health outcomes associated with earlyMenopause.

Menstrual Cycle Characteristics in Adolescence and Early Adulthood Are Associated With Risk of Early Natural Menopause

Results from this large prospective study of early menopause suggest an influence of accelerated oocyte depletion on risk and may help clarify the etiology of earlyMenopause.

Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study

Four common genetic variants identified by genome-wide association studies, had a significant impact on the odds of having EM in an independent cohort from the BGS, and as more variants are discovered they may be useful for predicting reproductive lifespan.

Family history as a predictor of early menopause.

Early menopause association with employment, smoking, divorced marital status and low leptin levels

  • F. SaraçK. ÖztekinG. Çelebi
  • Medicine
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2011
It is shown that early onset of menopause is correlated with smoking, employment status, divorced marital status and lower leptin levels.

Adult adiposity and risk of early menopause

Overall and abdominal adiposity were non-linearly associated with odds for early natural menopause with elevated odds observed among women who were underweight in early or mid-adulthood compared to lean-normal weight women.

Early menopause: A hazard to a woman's health

The traditional indicators to evaluate ovarian ageing are age, serum hormonal levels, anti-Mullerian hormone, antral follicle count, and ultrasonography of ovaries.