EM2487, a novel anti-HIV-1 antibiotic, produced by Streptomyces sp. Mer-2487: taxonomy, fermentation, biological properties, isolation and structure elucidation.

@article{Takeuchi1999EM2487AN,
  title={EM2487, a novel anti-HIV-1 antibiotic, produced by Streptomyces sp. Mer-2487: taxonomy, fermentation, biological properties, isolation and structure elucidation.},
  author={Hiromi Takeuchi and Naoki Asai and Kazunari Tanabe and Takazumi Kozaki and Mikako Fujita and Takashi Sakai and Akifumi Okuda and Nobuaki Naruse and Satoshi Yamamoto and Tomohiro Sameshima and N Heida and Kazuyuki Dobashi and Masanori Baba},
  journal={The Journal of antibiotics},
  year={1999},
  volume={52 11},
  pages={971-82}
}
For the purpose of discovering novel agents that inhibit HIV-1 replication at the transcriptional level, we have established cell lines reflecting the HIV-1 long terminal repeat-driven gene expression. Using these cell lines, we have screened approximately 10,000 microorganism products and found that the culture supernatant of Streptomyces sp. Mer-2487… CONTINUE READING