ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division

@article{Rasala2006ELYSIA,
  title={ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division},
  author={B. Rasala and A. Orjalo and Z. Shen and S. Briggs and D. Forbes},
  journal={Proceedings of the National Academy of Sciences},
  year={2006},
  volume={103},
  pages={17801 - 17806}
}
  • B. Rasala, A. Orjalo, +2 authors D. Forbes
  • Published 2006
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Nuclear pores span the nuclear envelope and act as gated aqueous channels to regulate the transport of macromolecules between the nucleus and cytoplasm, from individual proteins and RNAs to entire viral genomes. By far the largest subunit of the nuclear pore is the Nup107–160 complex, which consists of nine proteins and is critical for nuclear pore assembly. At mitosis, the Nup107–160 complex localizes to kinetochores, suggesting that it may also function in chromosome segregation. To… CONTINUE READING
    Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly.
    51
    The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells
    40
    Interplay between the transmembrane nucleoporin Pom121 and the Ran GTPase system
    Capture of AT-rich chromatin by ELYS recruits POM121 and NDC1 to initiate nuclear pore assembly.
    127

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