ELOPER: elongation of paired-end reads as a pre-processing tool for improved de novo genome assembly

@article{Silver2013ELOPEREO,
  title={ELOPER: elongation of paired-end reads as a pre-processing tool for improved de novo genome assembly},
  author={David H. Silver and Shay Ben-Elazar and Alexei Bogoslavsky and Itai Yanai},
  journal={Bioinformatics},
  year={2013},
  volume={29 11},
  pages={1455-7}
}
MOTIVATION Paired-end sequencing resulting in gapped short reads is commonly used for de novo genome assembly. Assembly methods use paired-end sequences in a two-step process, first treating each read-end independently, only later invoking the pairing to join the contiguous assemblies (contigs) into gapped scaffolds. Here, we present ELOPER, a pre-processing tool for pair-end sequences that produces a better read library for assembly programs. RESULTS ELOPER proceeds by simultaneously… CONTINUE READING
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