ELM—the database of eukaryotic linear motifs

@inproceedings{Dinkel2012ELMtheDO,
  title={ELM—the database of eukaryotic linear motifs},
  author={Holger Dinkel and Sushama Michael and Robert J. Weatheritt and Norman E. Davey and Kim Van Roey and Brigitte Altenberg and Grischa Toedt and Bora Uyar and Markus Seiler and Aidan Budd and Lisa J{\"o}dicke and Marcel A. Dammert and Christian Schroeter and Maria Hammer and Tobias Schmidt and Peter Jehl and Caroline McGuigan and Magdalena Dymecka and Claudia Chica and Katja Luck and Allegra Via and Andrew Chatr-aryamontri and Niall J. Haslam and Gleb Grebnev and Richard J. Edwards and Michel O. Steinmetz and Heike Meiselbach and Francesca Diella and Toby J. Gibson},
  booktitle={Nucleic Acids Research},
  year={2012}
}
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery… CONTINUE READING

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