ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties.

@article{Simone2003ELLassociatedF2,
  title={ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties.},
  author={Federico Simone and Roger T. Luo and Paul Polak and Joseph J. Kaberlein and Michael Thirman},
  journal={Blood},
  year={2003},
  volume={101 6},
  pages={
          2355-62
        }
}
The (11;19)(q23;p13.1) translocation in acute leukemia results in the formation of an MLL-ELL fusion protein. ELL is an RNA polymerase II elongation factor that interacts with the recently identified EAF1 protein. To characterize the normal functions of ELL and its aberrant activities when fused to MLL, we isolated a second protein that interacts with ELL named EAF2 for ELL Associated Factor 2. EAF2 is highly homologous to EAF1, with 58% identity and 74% amino acid conservation. Using specific… CONTINUE READING
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