ELISA screening of monoclonal antibodies to haptens: influence of the chemical structure of hapten-protein conjugates.

@article{Danilova1994ELISASO,
  title={ELISA screening of monoclonal antibodies to haptens: influence of the chemical structure of hapten-protein conjugates.},
  author={Natalia Danilova},
  journal={Journal of immunological methods},
  year={1994},
  volume={173 1},
  pages={111-7}
}
An analysis has been made of the influence of the chemical structure of hapten-protein conjugates on ELISA based screening monoclonal antibodies to haptens. Evidence has been obtained that the size of haptens should be taken into account. For haptens with a relatively large molecular weight, one can use a conjugate with a carrier protein differing from the immunogen. For small haptens, the screening should be conducted with a conjugate differing from the immunogen with respect to both the… CONTINUE READING