ELISA reveals a difference in the structure of substantia nigra ferritin in Parkinson's disease and incidental Lewy body compared to control.

@article{Koziorowski2007ELISARA,
  title={ELISA reveals a difference in the structure of substantia nigra ferritin in Parkinson's disease and incidental Lewy body compared to control.},
  author={Dariusz M. Koziorowski and Andrzej Friedman and Paolo Arosio and Paolo Santambrogio and Dorota Dziewulska},
  journal={Parkinsonism & related disorders},
  year={2007},
  volume={13 4},
  pages={214-8}
}
Iron released from ferritin may trigger oxidative stress leading to progressive neurodegeneration of substantia nigra resulting in Parkinson's disease (PD). Change in the structure of ferritin may allow an easier efflux of iron. We compared with the use of ELISA the structure of ferritin (concentrations of H and L ferritins) in substantia nigra (SN) in ten cases of PD, six of incidental Lewy body (ILB) cases and 20 controls. SN concentration of L ferritin in ILB (50.6+/-11.5 ng/mg) and in PD… CONTINUE READING
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