ELISA-quantitation of phosphorylated tau protein in the Alzheimer's disease brain.

  title={ELISA-quantitation of phosphorylated tau protein in the Alzheimer's disease brain.},
  author={Martin Herrmann and Sidonie Golombowski and Kurt Kr{\"a}uchi and Peter Frey and Chantal Mourton-Gilles and Christine Hulette and Christian Rosenberg and Franz Mueller-Spahn and C. Hock},
  journal={European neurology},
  volume={42 4},
A reliable, sensitive and specific sandwich ELISA for the quantitation of paired helical filament (PHF) tau in human brain was developed using well-defined monoclonal antibodies. We examined rapid-autopsy-derived brain tissue from 21 neuropathologically confirmed Alzheimer's disease (AD) patients and 14 nondemented controls, matched for age, sex and postmortem delay times. We demonstrated significant elevations of phosphorylated tau levels in the frontal and parietal cortex as well as in the… CONTINUE READING
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