ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior

@article{Dunn2019ELFN2IA,
  title={ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior},
  author={Henry A. Dunn and Stefano Zucca and Maria T. Dao and Cesare Orlandi and Kirill A. Martemyanov},
  journal={Molecular psychiatry},
  year={2019},
  volume={24},
  pages={1902 - 1919}
}
The functional characterization of the GPCR interactome has predominantly focused on intracellular binding partners; however, the recent emergence of transsynaptic GPCR complexes represents an additional dimension to GPCR function that has previously been unaccounted for in drug discovery. Here, we characterize ELFN2 as a novel postsynaptic adhesion molecule with a distinct expression pattern throughout the brain and a selective binding with group III metabotropic glutamate receptors (mGluRs… 
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