ELECTROPHYSIOLOGIC ANTAGONISM AND SYNERGISM OF POTASSIUM AND ANTIARRHYTHMIC AGENTS.

@article{Watanabe1963ELECTROPHYSIOLOGICAA,
  title={ELECTROPHYSIOLOGIC ANTAGONISM AND SYNERGISM OF POTASSIUM AND ANTIARRHYTHMIC AGENTS.},
  author={Y. Watanabe and Leonard S. Dreifus and William B. Likoff},
  journal={The American journal of cardiology},
  year={1963},
  volume={12},
  pages={
          702-10
        }
}
Abstract Interactions of potassium and antiarrhythmic agents on ventricular myocardial electrophysiology were studied in 25 isolated, perfused rabbit hearts by utilizing an intracellular microelectrode technic. Perfusion of quinidine (0.01 mg./ml.) in a normal concentration of potassium (5.6 mEq./L.) caused a significant decrease in the maximal rate of depolarization (−69.1%), heart rate (−40.4%) and the action potential duration per unit of time (−13.8%). Reduction in the height of action and… Expand
Interactions of Quinidine and Potassium on Atrioventricular Transmission
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The effects of quinidine and its interactions with potassium (K) on atrio-ventricular (A-V) conduction were studied in isolated, perfused rabbit hearts, utilizing microelectrode techniques to highlight the importance of these interrelationships in pharmacologic approach to A-V conduction disturbances. Expand
Electrophysiological and Antiarrhythmic Effects of Propranolol in Canine Acute Myocardial Ischemia
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The effects of propranolol in slowing conduction in the isChemic zone, in prolonging refractoriness, in reducing APD/ERP, and in reducing the disparity in APD between ischemic and normal zones may explain its demonstrated antiarrhythmic effects in acute myocardial ischemia. Expand
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It is proposed that DPH may either enhance or depress membrane activity in atrial tissue, and that both the direction and magnitude of effect are strongly dependent upon drug concentration, ionic milieu, and heart rate. Expand
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TLDR
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  • R. Dean
  • Chemistry, Medicine
  • Life sciences
  • 1969
TLDR
The technique presented is useful for differentiating quinidine from diphenylhydantion-type antiarrhythmic agents and is evidence for improved ventricular conduction. Expand
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Interactions of quinidlne and bretylium tosylate were studied in isolated perfused rabbit hearts by recording transmembrane potentials from the atrial fibers, the atrioventricular (A-V) junction and the ventricular fibers to find effects on A-V conduction and action potential duration. Expand
[Effect of propranolol, quinidine and lidocaine on spike and plateau potentials of canine ventricular muscle].
  • T. Inagaki
  • Medicine
  • Japanese circulation journal
  • 1971
TLDR
There is an need of re-evaluating the past studies where antiarrhythmic agents and other compounds were examined for their effects on overshoot, among other things. Expand
Comparative mechanisms of action of antiarrhythmic drugs.
TLDR
Clinically, it appears useful to categorize antiarrhythmic drugs into four groups in terms of their currently known mechanisms of action, and the effects of verapamil are sufficiently different from those of other known agents to allow the tentative conclusion that its fundamental mode of action represents a fourth (Group IV) class of antiarrHythmic action. Expand
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The maximum rate of depolarization and amplitude of action potentials from guinea pig ventricular fibers together with the threshold for stimulation have been measured over a range of stimulationExpand
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Evidence found suggests that the maximum rate of rise of the MAP may change independent of the membrane resting potential, and the effects of quinidine, procaine amide and pyrilamine on the membranes resting and action potentials of ventricular muscle fibers of the guinea pig heart have been examined. Expand
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During exposure to any of the antimalarial compounds tested, the normal inhibitory action of acetylcholine was converted to a stimulant action and there were slight differences in behaviour between proguanil and quinidine on the one hand, and chloroquine, mepacrine and pyrimethamine on the other. Expand
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A summary of experiments on the way changes in the ionic composition of the perfusate affect the size and shape of the action potential of the frog ventricle suggests that the nerve sodium-potassium hypothesis is applicable to cardiac muscle. Expand
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It was concluded that the effect of quinidine on the depolarization process was secondary to its effect on the processes of repolarization and recovery, and that in spontaneously beating right atria, or in isolated sinoatrial node preparations,Quinidine retarded the rate of repolarsization in pacemaker cells and reduced the spontaneous discharge rate of such cells. Expand
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The action of calcium ions and local anaesthetics on the magnitude of the diastolic membrane potential, the rate of rise and ' overshoot' of the action possible, the threshold potential and the membrane resistance of mammalian Purkinje fibres are described. Expand
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Observations suggest that quinidine produces its effects by depressing outward flux of K ions by blocking the intracellularly released acetylcholine in a manner similar to low K. Expand
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The accumulation of cell K seemed to be dependent mainly on an initial resting phase increase in potassium influx, and the increase in K exchange was apparently due to an increased resting potential potassium exchange with little or no alteration in exchange during the action potential. Expand
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TLDR
In the following pages some aspects of transmembrane potentials will be discussed, as they appear of particular interest to those concerned with the electrical phenomena of the beating heart as a whole. Expand
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TLDR
There is no evidence of cardiac depression, abnormalities in the electrocardiogram or significant anti-fibrillatory action during maximal drug-induced hypotension in intact anesthetized dogs using a quinidinerelated compound. Expand
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