ELB139 an agonist at the benzodiazepine binding site increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study

@article{Langen2007ELB139AA,
  title={ELB139 an agonist at the benzodiazepine binding site increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study},
  author={Barbara Langen and Chris Rundfeldt},
  journal={Pharmacology Biochemistry and Behavior},
  year={2007},
  volume={86},
  pages={79-85}
}
  • Barbara Langen, Chris Rundfeldt
  • Published 2007
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
  • Benzodiazepines induce an immediate anxiolytic activity at the expense of side effects such as sedation, tolerance and withdrawal. In contrast, selective serotonin receptor uptake inhibitors (SSRIs) are known to offer long-term symptom improvement without inducing tolerance and withdrawal, but with a delayed onset of the anxiolytic effect. ELB139 is a novel agonist at the benzodiazepine binding site with pronounced anxiolytic and anticonvulsant activity without inducing tolerance to both… CONTINUE READING