EIIaCre – Utility of a general deleter strain

  title={EIIaCre – Utility of a general deleter strain},
  author={Lisa Williams–Simons and Heiner Westphal},
  journal={Transgenic Research},
We conducted a survey of the utility of the EIIaCre strain of transgenic mice in which Cre is expressed in the unfertilized egg and in the zygote. Our survey is based on results reported by 10 laboratories that set up matings ofEIIaCre mice and gene-altered mutant strains that harbor lox-flanked genes. Cre action on 29 different lox-flanked loci resulted in progeny in which the DNA sequences between the lox sites were found to be deleted. In cases where proper quantitation was performed, the… CONTINUE READING