EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.

@article{Naslavsky2009EHD3RE,
  title={EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.},
  author={Naava Naslavsky and Jenna Elyse McKenzie and Nihal Altan-Bonnet and David R. Sheff and Steve Caplan},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 3},
  pages={389-400}
}
Depletion of EHD3 affects sorting in endosomes by altering the kinetics and route of receptor recycling to the plasma membrane. Here we demonstrate that siRNA knockdown of EHD3, or its interaction partner rabenosyn-5, causes redistribution of sorting nexin 1 (SNX1) to enlarged early endosomes and disrupts transport of internalized Shiga toxin B subunit (STxB) to the Golgi. Moreover, under these conditions, Golgi morphology appears as a series of highly dispersed and fragmented stacks that… CONTINUE READING