EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.

@article{Grandal2007EGFRvIIIED,
  title={EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.},
  author={Michael Vibo Grandal and Roza Zandi and Mikkel Wandahl Pedersen and Berthe Marie Willumsen and Bo van Deurs and Hans Skovgaard Poulsen},
  journal={Carcinogenesis},
  year={2007},
  volume={28 7},
  pages={1408-17}
}
EGFRvIII is a mutant variant of the epidermal growth factor receptor (EGFR) found exclusively in various cancer types. EGFRvIII lacks a large part of the extracellular domain and is unable to bind ligands; however, the receptor is constitutively phosphorylated and able to activate downstream signaling pathways. Failure to attenuate signaling by receptor down-regulation could be one of the major mechanisms by which EGFRvIII becomes oncogenic. Using a cell system expressing either EGFR or… CONTINUE READING

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